Our Technology

Filter to Forecast

Phase Advance’s Predictive Technology Platform is a modern sieve of AI & mathematical algorithms to identify medicines that will cure disease and become blockbusters – known as good black swan events – 7 to 14 years before clinical trials.

Cradle-to-Grave Modeling

Our nonlinear modeling mimics biological systems, creating a biomechanistic engine from the molecular to the whole-body level, from cellular to tissue to organ to system to entire body, as well as their complex interactions. This virtual cradle-to-grave modeling simulates patient development and disease progression from birth through adulthood, enabling dynamic prediction of therapeutic responses. 

Population Personalization

Clinical trial success can be affected by unique population differences such as genomics and even diet. An Alzheimer’s patient with particular biomarkers could respond differently to the same drug that benefits a patient from another genetic background. Our multiscale data integration combines genetic, clinical, pharmacometric, and population data in one seamless analytical framework.

Traditional Biopharma vs Phase Advance Timeline

Whether clients use our models just after discovery or after preclinical work, we can compare the future trial endpoints to market leaders, help design better trials, and reduce the target sample size. 

Minimum Required Inputs

Phase Advance models can forecast with minimal details about the molecule or biologic in question, regardless of therapy class.

Post PRE-CLINICAL DRUG Development Phase

  • All information required for post discovery use of our virtual models
  • Animal PKs if available
  • Animal model pharmacodynamic data

Immediately Post discovery

  • Chemical or antibody structure and class
  • Mechanism of action
  • Affinity, selectivity
  • Molecule-target receptor binding kinetics  with human protein
  • Potency and efficacy in in vitro assays
  • Proposed dosing route, predicted PKs (if any), metabolic stability
  • Any other information gathered during design and discovery

Our Disease Models

Our disease models align with the most in-demand therapeutic areas in biotech today, and are expanding continuously. 

Lung Infections
Liver Diseases (MASH, Viral Hepatitis, Drug-Induced Liver Injury)
Alzheimer’s Disease and Related Dementias, Parkinson’s & ALS
Immune-based Diseases & HIV
Metabolic Disease (Diabetes, Obesity, High Blood Pressure) 
Cancers Currently in Biopharma Focus

Contact Us

Let us know how we can help you.