Clients

Biopharma

Phase Advance technology is the sieve that separates the 3% winners from the haystack of losers in a portfolio at discovery phase & rank them for drug developers by extent of success  including predicting the “good” black swan event of blockbusters.

  • BioPharma spends $3B to develop one drug: failure is apparent only after spending the bulk of the money in clinical trials,12-15 years later
  • Phase Advance : 3 months to predict 10 molecules 
  • Current success rate from discovery to phase III is 3-10%: 97% failure
  • Phase Advance approach changes that to >99% success
  • Client will know future phase 3 outcomes before spending >99% of money

Contract Research Organizations

Phase Advance  is an engine that enables CROs to design successful clinical trials before they undertake them, thereby optimizing clinical trial design to make them smaller, faster, and more likely to lead to licensing.

 

We design successful clinical trials by generating:

  • Entire Phase 3 outcomes and time to outcome versus % of response patients before clinical trial is designed
  • Effect of genetic & ethnic diversity on clinical trial outcomes
  • Best disease stage when test drug is most effective- preventive Vs Early, Vs Middle Vs Late disease
  • Best clinical trial endpoints, biomarkers, sampling strategy & sample size 
  • Effect size of test compound versus market leader in different ethnic & genetic backgrounds to identify best clinical trial population

Investors

Phase Advance is the engine that helps investors only invest in molecules with >99% chance of succeeding in phase 3, before first-in-human studies, increasing the ROI for R&D from 1.2-6.8% to more than 90% & by changing the Net Present Value for molecules selected to go into drug development.

  • Scientific due diligence for therapeutics
  • De-risk investment from assets unlikely to work

  • Identify leads that will outperform competition

AI Discovery Vehicles

Phase Advance partners with AI drug discovery companies to carry their discoveries forward to the next stage: preclinical translational work to establish potential efficacy, PK/PD, and long-term outcomes for target diseases.

  • Prioritize leads with highest success rate

  • Identify leads that will outperform competition

  • Lead optimization insights and improved parameters or combo therapeutics

Contact Us

Let us know how we can help you.