Technology

Filter to Forecast

Phase Advance models are a modern sieve of AI & mathematical algorithms to identify medicines that will cure disease and become block busters (what we call “good black swan events”) 7 to 14 years before clinical trials.

Phase Advance: Validated & Mature

Stages Completed:
  • Non-linear mathematical models of disease progression and coding
  • Parametrization and training with clinical trial datasets
  • Validation with separate clinical trial datasets
  • Deployment in drug development
  • 99.94% accurate based on clinical trials completed years after

Population Personalization

Clinical trial success can be affected by unique population differences such as genomics and even diet. An Alzheimer’s patient with particular biomarkers could respond differently to the same drug that benefits a patient from another genetic background. Our models address this tremendous gap in clinical trials.

Traditional Biopharma vs Phase Advance Timeline

Whether clients use our models just after discovery or after preclinical work, we can compare the future trial endpoints to market leaders, help design better trials, and reduce the target sample size.

 

Minimum Required Inputs

Post PRE-CLINICAL DRUG Development Phase

Phase Advance in silico models of disease progression utilize minimal info to forecast Phase III outcomes.

  • All information required for post discovery use of our virtual models
  • Animal PKs if available
  • Animal model pharmacodynamic data

Immediately Post discovery

Phase Advance models can forecast with minimal details about the molecule or biologic in question.

  • Chemical or antibody structure and class
  • Mechanism of action
  • Affinity, selectivity
  • Molecule-target receptor binding kinetics  with human protein
  • Potency and efficacy in in vitro assays
  • Proposed dosing route, predicted PKs (if any), metabolic stability
  • Any other information gathered during design and discovery

Our Disease Models

Our disease models align with the most in-demand therapeutic areas in biotech today, and are expanding continuously. 

Lung Infections
Liver Diseases (MASH, Viral Hepatitis, Drug-Induced Liver Injury)
Alzheimer’s Disease and Related Dementias, Parkinson’s & ALS
Immune-based Diseases & HIV
Metabolic Disease (Diabetes, Obesity, High Blood Pressure) 
Cancers Currently in Biopharma Focus

Contact Us

Let us know how we can help you.